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Figure 1 | Journal of Circadian Rhythms

Figure 1

From: Toxic effects of methoxychlor on the episodic prolactin secretory pattern: Possible mediated effects of nitric oxide production

Figure 1

Individual episodic prolactin patterns during the whole bleeding period (B) and expanded detail of the pulsatile pattern of prolactin during the last 2 hr and 25 min of bleeding (A). The arrows indicate the prolactin pulses during the studied period. The left upper panel (I) shows the pulsatile pattern of prolactin in control rats treated with saline (vehicle of L-NAME). The left lower panel (II) shows the pulsatile pattern of prolactin in rats treated with L-NAME (rats were ip administered NĻ‰-nitro-L-arginine methyl ester at a dose of 10 mg/kg in saline, 60 minutes before the beginning of the bleeding period). The right upper panel (III) shows the pulsatile pattern of prolactin in rats treated with MTX (animals were sc treated with MTX al a dose of 25 mg/kg/day for 1 month). The right lower panel (IV) shows the pulsatile pattern of prolactin in rats treated with MTX and L-NAME (the animals were sc treated with methoxychlor (25 mg/kg/day) for 1 month and L-NAME at a dose of 10 mg/kg in saline, 60 minutes before beginning of the bleeding period).

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Journal of Circadian Rhythms

ISSN: 1740-3391