Circadian polymorphisms associated with affective disorders

Table 1 Polymorphisms associated with bipolar disorder

Gene	CHR	SNP	A1	A2	MAF	T	U	OR	CHISQ	P	EMP1	EMP2
*NPAS2*	2	rs1562313	A	G	0.213	208	165	1.261	4.957	0.0260	0.0484	0.9803
*PER2*	2	rs4663868	T	C	0.071	85	54	1.574	6.914	0.0086	0.0171	0.7330
*PER2*	2	rs2304669	G	A	0.164	131	167	0.784	4.349	0.0370	0.0416	0.9945
*PER2*	2	rs2304672	G	C	0.073	88	55	1.600	7.615	0.0058	0.0123	0.5972
*CLOCK*	4	rs3805148	C	A	0.366	255	197	1.294	7.442	0.0064	0.0092	0.6291
*CLOCK*	4	rs3736544	A	G	0.373	229	280	0.818	5.110	0.0238	0.0241	0.9728
*CLOCK*	4	rs12504300	C	G	0.282	188	138	1.362	7.669	0.0056	0.0094	0.5775
*CLOCK*	4	rs4864542	G	C	0.364	273	212	1.288	7.672	0.0056	0.0102	0.5759
*CLOCK*	4	rs12648271	C	G	0.285	227	182	1.247	4.951	0.0261	0.0369	0.9806
*CLOCK*	4	rs6850524	C	G	0.424	232	282	0.823	4.864	0.0274	0.0322	0.9840
*PPARGC1B*	5	rs7732671	C	G	0.068	65	42	1.548	4.944	0.0262	0.0213	0.9811
*PER1*	17	rs2585405	G	C	0.104	86	117	0.735	4.734	0.0296	0.0457	0.9881
*THRA*	17	rs939348	T	C	0.279	188	239	0.787	6.091	0.0136	0.0224	0.8729
*NR1D1*	17	rs2314339	T	C	0.130	90	147	0.612	13.710	0.0002	0.0005	0.0338
*NR1D1*	17	rs2071427	A	G	0.256	191	256	0.746	9.452	0.0021	0.0019	0.2852
*NR1D1*	17	rs2269457	G	A	0.239	171	214	0.799	4.803	0.0284	0.0292	0.9861
*CSNK1D*	17	rs4510078	A	G	0.021	18	38	0.474	7.143	0.0075	0.0175	0.6942

GENE: NCBI gene symbol. CHR: chromosome number. SNP: dbSNP symbol. A1 & A2: minor and major allele nucleotides. MAF: minor allele frequency. T: number of transmissions of the rare allele. U: number of untransmitted rare alleles. OR: odds ratio of TDT. CHISQ: Chi Square from TDT. P: probability of Chi Square. EMP1: empirical probability from simulation by PLINK. EMP2: corrected empirical P (Max T/familywise).