Figure 10
From: Transdisciplinary unifying implications of circadian findings in the 1950s
Circadian physiological variation in murine eosinophil counts (Eos). In four inbred strains and a hybrid (F1) stock (F Halberg and M Visscher. Proc Soc Exp Biol & med 75: 844–847, 1950). Note 1. Large genetic differences, gauged by one-way ANOVA across stocks at 08:00 (F=43.1; P < 0.001) and 00:00 (F=21.3; P < 0.001) representing differences in genome, and 2. Equally impressive diversity in time, in each stock, gauged by 08:00 vs. 00:00 difference, approximating, by only two timepoints, circadian component of chronome (t=11.3; P < 0.001 from paired t-test of relative 08:00 vs. 00:00 differences, expressed as percent of mean). The ever-present within-day difference can differ among stocks of mice.