Figure 17
From: Transdisciplinary unifying implications of circadian findings in the 1950s
Efficacy, safety and cost-effectiveness of chronotherapy (CT) versus traditional therapy (TT) with propranolol. Twenty patients per group; hypotensive effect is more pronounced on CT (dark gray) than on TT (light gray) (P < 0.05); SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure. Original studies by Rina Zaslavskaya on blood pressure chronotherapy compared with conventional treatment, eventually transferred from group studies with treatment at a fixed time in relation to the blood pressure acrophase, to individualized treatment optimized in the given patient with control by the monitored blood pressure analyzed as-one-goes by parameter tests and cumulative sums [80].