Figure 4

Resynchronization to phase shifts in the light–dark schedule. Nude and WT control mice were subjected to a 6-h shift in the light–dark schedule, and the transient needed to resynchronize to the new schedule was quantified. A. Time (days) needed to reentrain to the light–dark cycle in nude and WT mice subjected to a 6-h phase delay (2.7 ± 0.5 and 1.3 ± 0.2 days for nude and WT, respectively; p > 0.05 Mann Whitney test). B. Transient (days) needed to reentrain after 6-h phase advance of the LD cycle (7.5 ± 0.5 and 5.7 ± 0.2 days for nude and WT, respectively; p > 0.05 Mann Whitney test). C. Representative actograms of nude and WT mice subjected first to a 6-h phase delay and then (15 days later) to a 6-h phase advance of the LD cycle. Grey background represents time of lights-off.