Figure 5
Effect of MCAo on the shift of nightly melatonin onset. The impact of stroke on the melatonin rhythm for each animal was calculated by averaging the absolute daily melatonin onset shift (relative to pre-stroke baseline); see methods for a discussion of this calculation. The averages of these values determined for all animals with MCAo or sham surgery are displayed in bar graph format. The difference between average melatonin onset shift in the MCAo group was statistically significant relative to the control group (p < 0.02).