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Table 3 Single SNP analysis with corrected p- values = 0.10.

From: NPAS2 and PER2 are linked to risk factors of the metabolic syndrome

Variable Gene SNP P-value P-value corrected for multiple testing Beta- coefficient 95% CI
Fasting blood glucose level (Logarithmic) a DRD2 rs6277 0.003 0.051 -0.008 -0.012–-0.003
Waist circumference b PLCB4 rs6077510 0.004 0.085 2.0 0.63–3.4
Variable Gene SNP P-value P-value corrected for multiple testing Odds ratio 95% CI
High waist circumference c Per2 rs934945 0.003 0.062 1.9 1.2–3.0
Low HDL cholesterol d Vipr2 rs885863 0.004 0.069 1.5 1.1–2.0
Metabolic syndrome [IDF] f Per2 rs934945 0.004 0.070 1.9 1.2–2.9
  1. Single SNPs were analyzed using linear regression for continuous variables and logistic regression for dichotomous variables. Betacoefficients were calculated for continuous variables, odds ratios for dichotomous variables. The sex and age were controlled for these analyses. P-values corrected for multiple testing were calculated.
  2. a) The concentrations of blood glucose (mmol/L) after fasting at least 4 hours and without drinking on the same day. The variable was log-transformed to obtain the normal distribution.
  3. b) Waist circumference in centimeters
  4. c) Waist circumference 94 cm or more for men or 80 cm or more for women
  5. d) Serum high-density lipoprotein (HDL) cholesterol level was considered low when it was lower than 1.02 mmol/l for men or lower than 1.29 mmol/l for women.
  6. f) Metabolic syndrome was assessed using the International Diabetes Federations (IDF) criteria [IDF 2005] and defined as having waistline of 94 cm or more for men or 80 cm or more for women and at least two of the following components: the serum triglycerides level 1.7 mmol/l or higher, the serum high-density lipoprotein cholesterol level lower than 1.02 mmol/l for men or lower than 1.29 mmol/l for women, high blood pressure in terms of systolic pressure 130 mmHg or more or diastolic pressure 85 mmHg or more or treatment for previously diagnosed hypertension and raised fasting plasma glucose level 5.6 mmol/l or higher, or previously diagnosed type 2 diabetes.