Table 1 Methods used in recent papers examining non-traditional circadian oscillators.
Study | Lesion type | Done in DD? | Measure of Entrainment | Deprivation period | Homeostatic increase in measure? |
|---|---|---|---|---|---|
Clock gene deletion studies in RF | |||||
Fuller et al., 2008 (2) | Bmal1 ko | DD | Tb and LMA | Yes, 24 hrs, no anticipation in RF | No, reduced Tb and LMA |
Mistlberger al., 2008 (9) | Bmal1 ko | Mainly DD | Motion sensor | Ad lib after RF shows no entrainment | Yes, increased activity in RF |
Pendergast et al., 2009 (11) | Bmal1 ko | LD and DD | Wheel running | Yes, 48 hrs, no clear entrainment | Yes, increased running in RF and food deprivation |
Storch and Weitz, 2009 (10) | multiple clock genes | LD and DD | Wheel running | Not done | Yes, increased running in RF |
Clock gene deletion study in MASCO | |||||
Mohawk et al., 2009 (15) | Multiple clock genes | Mainly DD | Motion sensor for Bmal1; wheel running for rest | Not done | Yes, increased running after MA ingestion |
DMH lesion studies in RF | |||||
Gooley et al., 2006 (8) | excitotoxic | LD only | Tb and LMA | Yes, 44 hrs, after RF | No, reduced Tb and LMA in RF |
Landry et al., 2006 (5) | electrolytic | LD only | Motion sensor | Yes, 51 hrs after RF | Yes, increased activity in RF |
Landry et al., 2007 (4) | electrolytic | LD only | Motion sensor | Yes, 72 hrs after RF | Yes, increased activity in RF |
Moriya et al., 2009 (6) | electrolytic | LD, + DD test days | Motion sensor Tb, LMA | Yes, 46 or 58 hrs, but only first day shown | Does not say (activity normalized) |