CLOCK is suggested to associate with comorbid alcohol use and depressive disorders

Table 6 Haplotype association analysis of CLOCK.

SNP block	Haplotype	Sample set	Overall frequency	OR (95% CI)	P-value
rs3805151-rs2412648-rs11240-rs2412646	TTGC	1.	0.34	1.65 (1.14-2.28)	0.0077
		2.	0.33	Ns	Ns
		3.	0.34	1.50 (1.14-2.27)	0.0084
rs11240-rs2412646	GC	1.	0.34	1.65 (1.15-2.29)	0.0077
		2.	0.28	Ns	Ns
		3.	0.34	1.50 (1.14-2.27)	0.0084

Ns = non significant (P > 0.1). Odds ratio (OR): the ratio specific haplotype versus all other haplotypes among the cases, relative to the ratio specific haplotype versus all other haplotypes among the controls. Gender was used as covariate.