Aging related changes of circadian rhythmicity of cytotoxic lymphocyte subpopulations

Table 2 Integrated time-qualified 24-hours values expressed as AUC ± SE

	Healthy young-middle aged subjects	Healthy old aged subjects
CD3	1545.41 ± 42.23	1576.07 ± 25.85
CD4	891.33 ± 60.52	837.41 ± 32.41
CD8	603.73 ± 92.12	615.24 ± 30.21
CD4/CD8 ratio	39.40 ± 12.71	31.53 ± 1.35
CD16	142.50 ± 45.30	171.72 ± 31.63
CD20	264.12 ± 30.84	132.78 ± 21.23^•
CD25	76.12 ± 14.21	140.02 ± 24.25^•
DR+T cells	61.8 ± 10.23	109.5 ± 8.31^•
HLA-DR	327.05 ± 23.40	282.57 ± 20.42
TcRδ1	61.72 ± 13.71	86.23 ± 9.25
Cortisol	258.2 ± 13.4	310.6 ± 32.7^•

Units: % for lymphocyte subpopulations, μg/dl for cortisol all; parameters analyzed in all the subjects; p < 0.05^•