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Figure 3 | Journal of Circadian Rhythms

Figure 3

From: Chronic inhibition of endoplasmic reticulum calcium-release channels and calcium-ATPase lengthens the period of hepatic clock gene Per1

Figure 3

Per1-luc bioluminescence rhythms in liver explants treated with BAPTA-AM. (A) Representative daily records of Per1-luc expression in liver explants from AL (superior panel) and FR rats (inferior panel) during BAPTA-AM treatment (100 μM). The grey trace represents the DMSO control and the black trace the BAPTA-AM treated culture. The vertical dotted line represents the former meal time of the FR rats. The horizontal black line above the upper panel indicates the onset and duration of drug treatment which ended with washout of the drug on day 6, marked by the horizontal gray dashed line. The subjective night (or dark phase) is marked only on first day of culture. (B) Period from Per1-luc expression in liver cultures from AL (left bars) and FR (right bars) rats during BAPTA-AM treatment and after washout. All data plotted is presented as means ± SEM, n = 6. *Significant difference vs. the DMSO control and x means difference against washout (Bonferroni post hoc test, α = 0.01).

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