Figure 39

Harm or help: With or without chronobiologic patterning, the same total dose per week of Lentinan inhibits or enhances malignant growth, respectively, as compared to saline-treated controls. Key: treatment during active (A) or rest (R) span with sinusoidal weekly pattern (S) or equal daily doses (E) (P < 0.01). Difference in size corresponds to 50% difference in survival time; N = number of animals. Therapeutic optimization by timing drug administration according to biologic week and day. Timing treatment (with a sinusoidally changing vs. a fixed daily dose schedule with the same total dose per week) according to the biological week and preferably by the broader chronome can contribute to the difference between the inhibition or stimulation of a subsequently implanted malignant growth [186].