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Figure 6 | Journal of Circadian Rhythms

Figure 6

From: Diurnal and nutritional adjustments of intracellular Ca2+ release channels and Ca2+ ATPases associated with restricted feeding schedules in the rat liver

Figure 6

Zonal distribution of hepatic calcium-handling proteins. Zonal distribution of IP3R type 1 (panel A), IP3R type 2 (panel B), ryanodine receptor (panel C), SERCA type 2 (panel D), PMCA type 1 (panel E), and PMCA type 4 (panel F) are shown. A negative control (primary antibody omitted) is shown in the insert of panel A. In order to outline liver cells, rhodamine-conjugated phalloidin was used to detect actin associated to membrane as showed in the central images. Each figure shows semi-quantitative analysis of calcium-handling protein distribution (pericentral/periportal ratio) for each time (AL-ZT3, AL-ZT6, RF-ZT3, and RF-ZT6) and feeding condition (Fasted and Refed). * (p < 0.05) significant difference between AL time points (ZT3 vs ZT6); # (p < 0.05) AL vs RF; ♦ (p < 0.05) Fasted vs Refed groups and & (p < 0.05) Refed vs RF-ZT6 (Student´s t-test).

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Journal of Circadian Rhythms

ISSN: 1740-3391