Figure 4

Wheel-running behavior of Per2 ^−/− , Pml ^−/− and Per2 ^−/− /Pml ^−/− mice. The wheel-running actograms are double plotted showing a 12 h light/12 h dark cycle (LD) and a free-running period of 12 h dark/12 h dark (DD) cycles. The marker identifies the transition from LD to DD. Light pulse (LP) is indicated by the red asterisk. Actograms are representative of (A) a wild type mouse, (B) two representative Per2 ^−/− mice, (C) a representative Pml ^−/− mouse, and (D) two representative Per2 ^−/− / Pml ^−/− mice. Note the level of increased activity onset prior to ZT12 in the LD cycle.