Figure 4

Average SCN-AVP release patterns for cultures made from wildtype (upper panels) and Per1 ^m/m Per2 ^m/m double-mutant mice (lower panels). Percent of average release and SEM are plotted in external time, extrapolated from the time of sacrifice. Left panels show release patterns of mice sacrificed during LD, right panels show release patterns of mice sacrificed during the first day of DD. The very bottom right panel shows the profile of randomly selected samples. Asterisks indicate samples with a release level significantly deviating from the average (modified LSD test; P < 0.05). Horizontal dashed lines depict the SEMs. Black/grey bars indicate projected night and day, respectively.