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Figure 6 | Journal of Circadian Rhythms

Figure 6

From: Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice

Figure 6

Bmal1 and Per1 expression in a Bmal1 +/- control mouse and a Bmal1 -/- mouse that received intra-DMH AAV-BMAL1 injections bilaterally (modified, with permission, from Fuller et al [12]© (2008) AAAS http://www.sciencemag.org , Figure S4). Bmal1 expression was restored bilaterally and symmetrically by AAV-BMAL1 injections into the SCN (Panel D) or DMH (panel H) in Bmal1-/- mice. The panels do not include other structures that normally express Bmal1 in control mice to confirm that Bmal1 expression was restricted to the SCN or DMH in null mutants. Panels E and G illustrate Per1 expression in full coronal sections from a Bmal1+/- control mouse and a Bmal1-/- mouse that received an intra-DMH AAV-BMAL1 injection.

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Journal of Circadian Rhythms

ISSN: 1740-3391