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Figure 9 | Journal of Circadian Rhythms

Figure 9

From: Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice

Figure 9

Percent change of body weight in wildtype and Bmal1 -/- mice during restricted daily feeding (J. Pendergast and S. Yamazaki, unpublished). Body weights of wildtype mice (grey lines, N = 6) and Bmal1-/- mice (red and black lines, N = 7) during ad-lib food access (days -5 to 0) and 4-h/day restricted food access (days 1–10), expressed as percent change from day 0. A 25% body weight loss was established as an endpoint criterion, at which time mice were returned to ad-lib food access, to prevent mortality. Only one Bmal1-/- mouse (black line) remained above the endpoint criterion over the 10 days of restricted feeding.

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Journal of Circadian Rhythms

ISSN: 1740-3391