Figure 2

Graphs of body temperature for the animals in the corrected suplementary figure S3 in Fuller et al. [2]. The blue line represents the heterozygote animal shown in figures S3A and C, and the red line illustrates the Bmal1 -/- animal with an injection of AAV-Cre into the suprachiasmatic nucleus, shown in figures S3B and D, across the entire five day period in restricted feeding from which the summary graphs in panels C and D were derived. Note that the heterozygote animal (blue) had a normal circadian variation in body temperature, and a robust spike in temperature peaking just around the onset of time of feeding (arrows), as shown in the summary figure S3C. The animal with the injection of AAV-Cre into the suprachiasmatic nucleus had reconstitution of the daily circadian pattern, but no evidence of the anticipatory increase in body temperature prior to feeding, although there was an increase each day after feeding, consistent with the summary figure S3D.