Figure 3
From: Time-of-day dependence of neurological deficits induced by sodium nitroprusside in young mice
Variations of ataxia according to the dosing time of sodium nitroprusside in eight-week old male and female mice. The three panels refer to three doses: 3 (a), 3.3 (b) and 3.6 mg.kg-1 (c). Values are the mean ± SEM of four independent experiments. The black bar corresponds to the dark period. Maximum and minimum of motor incoordination correspond, irrespective to the gender and dose, to drug dosing at 1 and 13 HALO, respectively. A dosing time-related effect was statistically validated by χ2 test (P < 0.00005) in both genders. Circadian (τ = 24 h) rhythms were confirmed by Cosinor analysis with correction for multiple testing only in mice treated with 3.6 mg.kg-1 (P < 0.05).